Assay Detail
Binding
CHEMBL873267
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Binding affinity towards human Tachykinin receptor 1 by the displacement of [125I]- Substance P in CHO Cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Morpholine-based substance P antagonists: assessment of the 3-point binding model
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.12 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16192 | CP-96345 | — | 1 | 9.30 |
| CHEMBL441225 | CP-99994 | — | 1 | 9.00 |
| CHEMBL56458 | — | — | 1 | 7.06 |
| CHEMBL58774 | — | — | 1 | 5.95 |
| CHEMBL292237 | — | — | 1 | 5.82 |
| CHEMBL431725 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16192 | CP-96345 | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL441225 | CP-99994 | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL56458 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL58774 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL292237 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL431725 | — | IC50 | = | 2530.0 | nM | 5.60 |