Assay Detail
Binding
CHEMBL873290
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for binding affinity against Ionotropic glutamate receptor kainate using [3H]kainate as a radioligand.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic kainate (CHEMBL2109241) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Pyrrolylquinoxalinediones: A new class of AMPA receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.58 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268284 | — | — | 1 | 6.39 |
| CHEMBL12448 | — | — | 1 | 5.82 |
| CHEMBL222519 | NBQX | — | 1 | 5.58 |
| CHEMBL12730 | — | — | 1 | 5.31 |
| CHEMBL305534 | — | — | 1 | 5.28 |
| CHEMBL99012 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268284 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL12448 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL222519 | NBQX | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL12730 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL305534 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL99012 | — | Ki | = | 8500.0 | nM | 5.07 |