Assay Detail
Binding
CHEMBL873369
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Inhibitory activity against matrix metalloprotease-8
21
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent and selective carboxylic acid-based inhibitors of matrix metalloproteinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 8.20 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311266 | — | — | 2 | 9.30 |
| CHEMBL82169 | — | — | 1 | 8.92 |
| CHEMBL83368 | — | — | 1 | 8.82 |
| CHEMBL253680 | — | — | 1 | 8.82 |
| CHEMBL311004 | — | — | 1 | 8.74 |
| CHEMBL315114 | — | — | 1 | 8.62 |
| CHEMBL83955 | — | — | 1 | 8.57 |
| CHEMBL83282 | — | — | 1 | 8.52 |
| CHEMBL402745 | — | — | 1 | 8.52 |
| CHEMBL85374 | — | — | 1 | 8.49 |
| CHEMBL312100 | — | — | 1 | 8.44 |
| CHEMBL79267 | — | — | 1 | 8.28 |
| CHEMBL311097 | — | — | 1 | 8.17 |
| CHEMBL10454 | — | — | 1 | 8.03 |
| CHEMBL44383 | — | — | 1 | 7.97 |
| CHEMBL82113 | — | — | 1 | 7.59 |
| CHEMBL79906 | — | — | 1 | 7.52 |
| CHEMBL313340 | — | — | 1 | 7.35 |
| CHEMBL85026 | — | — | 1 | 6.53 |
| CHEMBL83616 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311266 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL82169 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL83368 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL253680 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL311004 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL315114 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL83955 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL83282 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL402745 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL85374 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL311266 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL312100 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL79267 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL311097 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL10454 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL44383 | — | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL82113 | — | IC50 | = | 25.8 | nM | 7.59 |
| CHEMBL79906 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL313340 | — | IC50 | = | 44.8 | nM | 7.35 |
| CHEMBL85026 | — | IC50 | = | 294.0 | nM | 6.53 |
| CHEMBL83616 | — | IC50 | = | 303.0 | nM | 6.52 |