Assay Detail
Functional
CHEMBL873381
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-tumor activity against human UACC375 melanoma cell lines by using MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | UACC-375 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Amino-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H- dibenz[de,h]isoquinoline-1,3-diones. Synthesis, antitumor activity, and quantitative structure--activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.66 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145869 | — | — | 1 | 8.02 |
| CHEMBL174780 | — | — | 1 | 7.82 |
| CHEMBL173888 | — | — | 1 | 7.60 |
| CHEMBL148141 | — | — | 1 | 7.42 |
| CHEMBL147597 | — | — | 1 | 7.35 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 7.32 |
| CHEMBL146101 | — | — | 1 | 7.21 |
| CHEMBL145826 | — | — | 1 | 7.21 |
| CHEMBL290677 | AZONAFIDE | — | 1 | 7.15 |
| CHEMBL174108 | — | — | 1 | 7.14 |
| CHEMBL148263 | — | — | 1 | 7.12 |
| CHEMBL146104 | — | — | 1 | 7.01 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.95 |
| CHEMBL179290 | — | — | 1 | 6.88 |
| CHEMBL41290 | — | — | 1 | 6.83 |
| CHEMBL356939 | — | — | 1 | 6.60 |
| CHEMBL175042 | — | — | 1 | 6.14 |
| CHEMBL148027 | — | — | 1 | 6.02 |
| CHEMBL177706 | — | — | 1 | 6.01 |
| CHEMBL177707 | — | — | 1 | 5.92 |
| CHEMBL147556 | — | — | 1 | 5.80 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.69 |
| CHEMBL178168 | — | — | 1 | 5.61 |
| CHEMBL178220 | — | — | 1 | 5.14 |
| CHEMBL146315 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145869 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL174780 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL173888 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL148141 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL147597 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL146101 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL145826 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL290677 | AZONAFIDE | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL174108 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL148263 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL146104 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL179290 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL41290 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL356939 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL175042 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL148027 | — | IC50 | = | 949.0 | nM | 6.02 |
| CHEMBL177706 | — | IC50 | = | 973.0 | nM | 6.01 |
| CHEMBL177707 | — | IC50 | = | 1214.0 | nM | 5.92 |
| CHEMBL147556 | — | IC50 | = | 1601.0 | nM | 5.80 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 2031.0 | nM | 5.69 |
| CHEMBL178168 | — | IC50 | = | 2433.0 | nM | 5.61 |
| CHEMBL178220 | — | IC50 | = | 7290.0 | nM | 5.14 |
| CHEMBL146315 | — | IC50 | = | 23025.0 | nM | 4.64 |