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Assay Detail

CHEMBL873405

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Binding
Inhibition constant against human plasminogen
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Plasminogen (CHEMBL1801)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin.
Tidwell RR, Geratz JD, Dubovi EJ.
J Med Chem (1983) 26 : 294 -298
PubMed 6219223 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 24 4.83 5.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL99951 1 5.58
CHEMBL101027 1 5.53
CHEMBL101672 1 5.42
CHEMBL101261 1 5.41
CHEMBL103649 1 5.09
CHEMBL102148 1 5.09
CHEMBL317713 1 4.37
CHEMBL101067 1 4.22
CHEMBL321960 1 4.21
CHEMBL101726 1 4.18
CHEMBL101559 1 4.00
CHEMBL322894 1 -
CHEMBL101878 1 -
CHEMBL102141 1 -
CHEMBL100296 1 -
CHEMBL319122 1 -
CHEMBL102009 1 -
CHEMBL26490 1 -
CHEMBL329730 1 -
CHEMBL101343 1 -
CHEMBL102002 1 -
CHEMBL415700 1 -
CHEMBL321524 1 -
CHEMBL100569 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL99951 Ki = 2650.0 nM 5.58
CHEMBL101027 Ki = 2930.0 nM 5.53
CHEMBL101672 Ki = 3830.0 nM 5.42
CHEMBL101261 Ki = 3900.0 nM 5.41
CHEMBL103649 Ki = 8180.0 nM 5.09
CHEMBL102148 Ki = 8190.0 nM 5.09
CHEMBL317713 Ki = 43000.0 nM 4.37
CHEMBL101067 Ki = 60000.0 nM 4.22
CHEMBL321960 Ki = 61500.0 nM 4.21
CHEMBL101726 Ki = 65600.0 nM 4.18
CHEMBL101559 Ki = 100000.0 nM 4.00
CHEMBL322894 Ki > 400000.0 nM -
CHEMBL101878 Ki > 1000000.0 nM -
CHEMBL102141 Ki > 700000.0 nM -
CHEMBL100296 Ki > 400000.0 nM -
CHEMBL319122 Ki = 164000.0 nM -
CHEMBL102009 Ki > 200000.0 nM -
CHEMBL26490 Ki = 112000.0 nM -
CHEMBL329730 Ki > 100000.0 nM -
CHEMBL101343 Ki = 844000.0 nM -
CHEMBL102002 Ki ~ 200000.0 nM -
CHEMBL415700 Ki > 1000000.0 nM -
CHEMBL321524 Ki > 1000000.0 nM -
CHEMBL100569 Ki = 111000.0 nM -