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Assay Detail

CHEMBL873408

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
The inhibition constant against human plasmin
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Plasminogen (CHEMBL1801)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Tetrahydro-isoquinoline-based factor Xa inhibitors.
Kucznierz R, Grams F, Leinert H, Marzenell K, Engh RA, von der Saal W.
J Med Chem (1998) 41 : 4983 -4994
PubMed 9836616 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 19 4.59 5.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL144637 1 5.00
CHEMBL358566 1 5.00
CHEMBL148343 1 5.00
CHEMBL539053 DX-9065A HYDROCHLORIDE HYDRATE 1 4.96
CHEMBL435028 1 4.85
CHEMBL344281 1 4.60
CHEMBL147707 1 4.60
CHEMBL148323 1 4.60
CHEMBL147436 1 4.60
CHEMBL146940 1 4.60
CHEMBL357832 1 4.58
CHEMBL144079 1 4.40
CHEMBL148357 1 4.36
CHEMBL344309 1 4.35
CHEMBL356973 1 4.30
CHEMBL342568 1 4.30
CHEMBL147789 1 4.30
CHEMBL344305 1 4.28
CHEMBL439982 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL144637 Ki = 10000.0 nM 5.00
CHEMBL358566 Ki = 10000.0 nM 5.00
CHEMBL148343 Ki = 10000.0 nM 5.00
CHEMBL539053 DX-9065A HYDROCHLORIDE HYDRATE Ki = 11000.0 nM 4.96
CHEMBL435028 Ki = 14000.0 nM 4.85
CHEMBL344281 Ki = 25000.0 nM 4.60
CHEMBL147707 Ki = 25000.0 nM 4.60
CHEMBL148323 Ki = 25000.0 nM 4.60
CHEMBL147436 Ki = 25000.0 nM 4.60
CHEMBL146940 Ki = 25000.0 nM 4.60
CHEMBL357832 Ki = 26000.0 nM 4.58
CHEMBL144079 Ki = 40000.0 nM 4.40
CHEMBL148357 Ki = 44000.0 nM 4.36
CHEMBL344309 Ki = 45000.0 nM 4.35
CHEMBL356973 Ki = 50000.0 nM 4.30
CHEMBL342568 Ki = 50000.0 nM 4.30
CHEMBL147789 Ki = 50000.0 nM 4.30
CHEMBL344305 Ki = 52000.0 nM 4.28
CHEMBL439982 Ki = - nM -