Assay Detail
Binding
CHEMBL873416
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Inhibition of HIV protease at pH 6.4, 37 degree C
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Hydroxyethylamine analogues of the p17/p24 substrate cleavage site are tight-binding inhibitors of HIV protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.72 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3143731 | — | — | 1 | 9.22 |
| CHEMBL109500 | — | — | 1 | 9.18 |
| CHEMBL2371768 | — | — | 1 | 7.75 |
| CHEMBL2311136 | — | — | 1 | 7.68 |
| CHEMBL3143736 | — | — | 1 | 7.68 |
| CHEMBL3143738 | — | — | 1 | 7.16 |
| CHEMBL3143739 | — | — | 1 | 6.38 |
| CHEMBL2371777 | — | — | 1 | 6.11 |
| CHEMBL52494 | — | — | 1 | 5.97 |
| CHEMBL417012 | — | — | 1 | 5.58 |
| CHEMBL3143737 | — | — | 1 | 5.34 |
| CHEMBL2371769 | — | — | 1 | 4.89 |
| CHEMBL49026 | — | — | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3143731 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL109500 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL2371768 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL2311136 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL3143736 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL3143738 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL3143739 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL2371777 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL52494 | — | Ki | = | 1060.0 | nM | 5.97 |
| CHEMBL417012 | — | Ki | = | 2640.0 | nM | 5.58 |
| CHEMBL3143737 | — | Ki | = | 4520.0 | nM | 5.34 |
| CHEMBL2371769 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL49026 | — | Ki | = | 39000.0 | nM | 4.41 |