Assay Detail
Binding
CHEMBL873418
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Evaluated for inhibitory activity against HIV-1 protease
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Peptidomimetic inhibitors of human immunodeficiency virus protease (HIV-PR): Design, enzyme binding and selectivity, antiviral efficacy, and cell permeability properties
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 7.68 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL168093 | — | — | 1 | 8.40 |
| CHEMBL165706 | — | — | 1 | 8.30 |
| CHEMBL170551 | — | — | 1 | 8.10 |
| CHEMBL166175 | — | — | 1 | 8.10 |
| CHEMBL433729 | — | — | 1 | 8.10 |
| CHEMBL167514 | — | — | 1 | 8.05 |
| CHEMBL166640 | — | — | 1 | 8.00 |
| CHEMBL355867 | — | — | 1 | 7.85 |
| CHEMBL166052 | — | — | 1 | 7.80 |
| CHEMBL165480 | — | — | 1 | 7.52 |
| CHEMBL168779 | — | — | 1 | 7.33 |
| CHEMBL168651 | — | — | 1 | 7.21 |
| CHEMBL167442 | — | — | 1 | 7.21 |
| CHEMBL352967 | — | — | 1 | 7.12 |
| CHEMBL355715 | — | — | 1 | 6.10 |
| CHEMBL353108 | — | — | 1 | - |
| CHEMBL3350189 | — | — | 1 | - |
| CHEMBL168675 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL168093 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL165706 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL170551 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL166175 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL433729 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL167514 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL166640 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL355867 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL166052 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL165480 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL168779 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL168651 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL167442 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL352967 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL355715 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL353108 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3350189 | — | Ki | < | 1.0 | nM | - |
| CHEMBL168675 | — | Ki | > | 1000.0 | nM | - |