Assay Detail
Binding
CHEMBL873438
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In vitro inhibitory activity against human muscle glycogen phosphorylase a (HMGPa)
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Muscle tissue |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.23 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115651 | — | — | 1 | 8.22 |
| CHEMBL113736 | — | — | 1 | 8.08 |
| CHEMBL423509 | — | — | 1 | 8.00 |
| CHEMBL326950 | — | — | 1 | 7.97 |
| CHEMBL115341 | — | — | 1 | 7.96 |
| CHEMBL114226 | — | — | 1 | 7.89 |
| CHEMBL114846 | — | — | 1 | 7.70 |
| CHEMBL114731 | — | — | 1 | 7.58 |
| CHEMBL113762 | — | — | 1 | 7.54 |
| CHEMBL115441 | — | — | 1 | 7.43 |
| CHEMBL334272 | — | — | 1 | 7.39 |
| CHEMBL114271 | — | — | 1 | 7.28 |
| CHEMBL117483 | — | — | 1 | 7.04 |
| CHEMBL114950 | — | — | 1 | 6.86 |
| CHEMBL323707 | — | — | 1 | 6.76 |
| CHEMBL326810 | — | — | 1 | 6.75 |
| CHEMBL115395 | — | — | 1 | 6.73 |
| CHEMBL115045 | — | — | 1 | 6.63 |
| CHEMBL114858 | — | — | 1 | 5.92 |
| CHEMBL324357 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115651 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL113736 | — | IC50 | = | 8.28 | nM | 8.08 |
| CHEMBL423509 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL326950 | — | IC50 | = | 10.61 | nM | 7.97 |
| CHEMBL115341 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL114226 | — | IC50 | = | 12.9 | nM | 7.89 |
| CHEMBL114846 | — | IC50 | = | 19.9 | nM | 7.70 |
| CHEMBL114731 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL113762 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL115441 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL334272 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL114271 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL117483 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL114950 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL323707 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL326810 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL115395 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL115045 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL114858 | — | IC50 | = | 1195.0 | nM | 5.92 |
| CHEMBL324357 | — | IC50 | = | 15000.0 | nM | 4.82 |