Assay Detail
Binding
CHEMBL873446
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [3H]Oxo-Mas binding to M1 and M4 receptors in rat brain homogenate.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Muscarinic agonists with antipsychotic-like activity: structure-activity relationships of 1,2,5-thiadiazole analogues with functional dopamine antagonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 8.61 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139316 | — | — | 1 | 9.33 |
| CHEMBL344872 | — | — | 1 | 9.30 |
| CHEMBL137804 | — | — | 1 | 9.28 |
| CHEMBL336449 | — | — | 1 | 9.19 |
| CHEMBL134579 | — | — | 1 | 9.19 |
| CHEMBL137490 | — | — | 1 | 8.89 |
| CHEMBL137537 | — | — | 1 | 8.89 |
| CHEMBL343502 | — | — | 1 | 8.85 |
| CHEMBL136807 | VEDACLIDINE | 2.0 | 1 | 8.66 |
| CHEMBL343155 | — | — | 1 | 8.64 |
| CHEMBL139075 | — | — | 1 | 8.60 |
| CHEMBL344624 | — | — | 1 | 8.54 |
| CHEMBL336227 | — | — | 1 | 8.48 |
| CHEMBL139054 | — | — | 1 | 8.44 |
| CHEMBL136194 | — | — | 1 | 8.38 |
| CHEMBL7634 | OXOTREMORINE | — | 1 | 8.30 |
| CHEMBL344669 | — | — | 1 | 8.21 |
| CHEMBL343731 | — | — | 1 | 8.00 |
| CHEMBL137292 | — | — | 1 | 7.88 |
| CHEMBL550 | PILOCARPINE | 4.0 | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139316 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL344872 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL137804 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL336449 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL134579 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL137490 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL137537 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL343502 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL136807 | VEDACLIDINE | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL343155 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL139075 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL344624 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL336227 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL139054 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL136194 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL7634 | OXOTREMORINE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL344669 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL343731 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL137292 | — | IC50 | = | 13.3 | nM | 7.88 |
| CHEMBL550 | PILOCARPINE | IC50 | = | 67.0 | nM | 7.17 |