Assay Detail
Functional
CHEMBL873450
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro antagonistic activity against alpha-1A receptor in dog prostate.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Tissue | Prostate gland |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity studies for a novel series of bicyclic substituted hexahydrobenz[e]isoindole alpha1A adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 8.59 | 9.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62033 | — | — | 1 | 9.83 |
| CHEMBL836 | TAMSULOSIN | 4.0 | 1 | 9.54 |
| CHEMBL293695 | — | — | 1 | 9.45 |
| CHEMBL445325 | — | — | 1 | 9.23 |
| CHEMBL291303 | — | — | 1 | 9.01 |
| CHEMBL707 | DOXAZOSIN | 4.0 | 1 | 7.59 |
| CHEMBL611 | TERAZOSIN | 4.0 | 1 | 7.44 |
| CHEMBL709 | ALFUZOSIN | 4.0 | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62033 | — | Kd | = | 0.1479 | nM | 9.83 |
| CHEMBL836 | TAMSULOSIN | Kd | = | 0.2884 | nM | 9.54 |
| CHEMBL293695 | — | Kd | = | 0.3548 | nM | 9.45 |
| CHEMBL445325 | — | Kd | = | 0.5888 | nM | 9.23 |
| CHEMBL291303 | — | Kd | = | 0.9772 | nM | 9.01 |
| CHEMBL707 | DOXAZOSIN | Kd | = | 25.7 | nM | 7.59 |
| CHEMBL611 | TERAZOSIN | Kd | = | 36.31 | nM | 7.44 |
| CHEMBL709 | ALFUZOSIN | Kd | = | 218.78 | nM | 6.66 |