Assay Detail
Binding
CHEMBL873456
Review assay metadata, readout intent, target linkage, and publication context from the same page.
inhibition of cAMP-specific phosphodiesterase 4 (PDE4) was determined in cytosol from human neutrophils
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of cis-tetrahydrophthalazinone/pyridazinone hybrids: a novel series of potent dual PDE3/PDE4 inhibitory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.90 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61699 | — | — | 1 | 8.70 |
| CHEMBL304715 | — | — | 1 | 8.60 |
| CHEMBL60026 | — | — | 1 | 8.40 |
| CHEMBL62131 | — | — | 1 | 8.40 |
| CHEMBL64824 | — | — | 1 | 8.40 |
| CHEMBL64544 | — | — | 1 | 8.20 |
| CHEMBL64052 | — | — | 1 | 8.20 |
| CHEMBL294327 | — | — | 1 | 8.10 |
| CHEMBL293589 | — | — | 1 | 8.10 |
| CHEMBL59953 | — | — | 1 | 8.10 |
| CHEMBL60839 | — | — | 1 | 7.90 |
| CHEMBL61116 | — | — | 1 | 7.80 |
| CHEMBL60999 | — | — | 1 | 7.80 |
| CHEMBL61822 | — | — | 1 | 7.80 |
| CHEMBL303550 | — | — | 1 | 7.70 |
| CHEMBL59996 | — | — | 1 | 7.10 |
| CHEMBL61667 | — | — | 1 | 7.00 |
| CHEMBL511115 | CILOMILAST | 3.0 | 1 | 7.00 |
| CHEMBL313842 | ZARDAVERINE | 2.0 | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61699 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL304715 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL60026 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL62131 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL64824 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL64544 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL64052 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL294327 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL293589 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL59953 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL60839 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL61116 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL60999 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL61822 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL303550 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL59996 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL61667 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL511115 | CILOMILAST | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL313842 | ZARDAVERINE | IC50 | = | 158.49 | nM | 6.80 |