Assay Detail
Binding
CHEMBL873471
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity was measured against the Tachykinin receptor 1 in bovine retina using [3H]SP
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Retina |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Derivation of a three-dimensional pharmacophore model of substance P antagonists bound to the neurokinin-1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.68 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121852 | — | — | 1 | 7.82 |
| CHEMBL118565 | — | — | 1 | 7.59 |
| CHEMBL120190 | — | — | 1 | 7.52 |
| CHEMBL101420 | — | — | 1 | 6.51 |
| CHEMBL289573 | — | — | 1 | 5.86 |
| CHEMBL297134 | — | — | 1 | 5.86 |
| CHEMBL102525 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121852 | — | IC50 | = | 15.14 | nM | 7.82 |
| CHEMBL118565 | — | IC50 | = | 25.7 | nM | 7.59 |
| CHEMBL120190 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL101420 | — | IC50 | = | 309.03 | nM | 6.51 |
| CHEMBL289573 | — | IC50 | = | 1380.38 | nM | 5.86 |
| CHEMBL297134 | — | IC50 | = | 1380.38 | nM | 5.86 |
| CHEMBL102525 | — | IC50 | = | 2691.53 | nM | 5.57 |