Assay Detail
Functional
CHEMBL873591
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against EMT6 murine cell line
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | EMT6 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.33 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL356845 | — | — | 1 | 4.82 |
| CHEMBL151905 | — | — | 1 | 4.55 |
| CHEMBL153152 | — | — | 1 | 4.31 |
| CHEMBL347509 | — | — | 1 | 4.20 |
| CHEMBL152056 | — | — | 1 | 4.19 |
| CHEMBL357531 | — | — | 1 | 4.14 |
| CHEMBL356820 | — | — | 1 | 4.11 |
| CHEMBL153380 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL356845 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL151905 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL153152 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL347509 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL152056 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL357531 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL356820 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL153380 | — | IC50 | = | 129000.0 | nM | - |