Assay Detail
Binding
CHEMBL873748
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of p70 S6 kinase
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Expert |
Target
Ribosomal protein S6 kinase (P70S6K) (CHEMBL2111330) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Identification of isothiazole-4-carboxamidines derivatives as a novel class of allosteric MEK1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.79 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL253116 | — | — | 1 | 6.00 |
| CHEMBL437331 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL253116 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL437331 | — | IC50 | = | 2620.0 | nM | 5.58 |