Assay Detail
Functional
CHEMBL873856
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In vitro inhibitory activity of compound against induced cytotoxicity in multidrug-resistant MCF-7/ADR breast cancer cell line
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI/ADR-RES |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Total synthesis and anti-tubulin activity of epi-c3 analogues of cryptophycin-24.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.50 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441018 | CRYPTOPHYCIN A | — | 1 | 7.75 |
| CHEMBL264224 | ARENASTATIN A | — | 2 | 6.60 |
| CHEMBL123698 | — | — | 1 | 6.04 |
| CHEMBL124249 | — | — | 1 | - |
| CHEMBL332430 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441018 | CRYPTOPHYCIN A | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL264224 | ARENASTATIN A | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL123698 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL264224 | ARENASTATIN A | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL124249 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL332430 | — | IC50 | > | 25000.0 | nM | - |