Assay Detail
Functional
CHEMBL873859
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of LoVo (human colon cancer) cell growth.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LoVo |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and characterization of the antitumor activities of analogues of meridine, a marine pyridoacridine alkaloid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.99 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL323049 | — | — | 1 | 10.00 |
| CHEMBL322502 | — | — | 1 | 9.52 |
| CHEMBL110742 | — | — | 1 | 8.15 |
| CHEMBL322742 | — | — | 1 | 7.70 |
| CHEMBL109640 | — | — | 1 | 7.40 |
| CHEMBL113387 | — | — | 1 | 7.30 |
| CHEMBL111490 | — | — | 1 | 7.30 |
| CHEMBL109479 | — | — | 1 | 7.22 |
| CHEMBL327101 | MERIDINE | — | 1 | 7.16 |
| CHEMBL324780 | — | — | 1 | 7.16 |
| CHEMBL111477 | — | — | 1 | 7.10 |
| CHEMBL322816 | — | — | 1 | 7.05 |
| CHEMBL323280 | — | — | 1 | 7.05 |
| CHEMBL324884 | — | — | 1 | 7.00 |
| CHEMBL112938 | — | — | 1 | 6.16 |
| CHEMBL110525 | — | — | 1 | 6.16 |
| CHEMBL111383 | — | — | 1 | 6.10 |
| CHEMBL424062 | — | — | 1 | 6.10 |
| CHEMBL111845 | — | — | 1 | 6.05 |
| CHEMBL111300 | — | — | 1 | 5.54 |
| CHEMBL111249 | — | — | 1 | 5.41 |
| CHEMBL111359 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL323049 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL322502 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL110742 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL322742 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL109640 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL113387 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL111490 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL109479 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL327101 | MERIDINE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL324780 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL111477 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL322816 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL323280 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL324884 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL112938 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL110525 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL111383 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL424062 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL111845 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL111300 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL111249 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL111359 | — | IC50 | = | 5700.0 | nM | 5.24 |