Assay Detail
Binding
CHEMBL873880
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Inhibitory activity against HSV-1 Thymidine Kinase (HSV-1 TK)
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Thymidine kinase (CHEMBL1820) ↗| Type | SINGLE PROTEIN |
| Organism | Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1) |
Publication
Nucleoside analogues as highly potent and selective inhibitors of herpes simplex virus thymidine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 8.05 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45114 | — | — | 1 | 9.72 |
| CHEMBL288683 | — | — | 1 | 9.57 |
| CHEMBL432111 | — | — | 1 | 9.52 |
| CHEMBL44047 | — | — | 1 | 9.18 |
| CHEMBL46821 | — | — | 1 | 9.07 |
| CHEMBL290528 | — | — | 1 | 9.03 |
| CHEMBL42459 | — | — | 1 | 9.02 |
| CHEMBL46884 | — | — | 1 | 9.00 |
| CHEMBL47094 | — | — | 1 | 9.00 |
| CHEMBL46633 | — | — | 1 | 8.82 |
| CHEMBL295657 | — | — | 1 | 8.82 |
| CHEMBL289560 | — | — | 1 | 8.80 |
| CHEMBL42389 | — | — | 1 | 8.77 |
| CHEMBL42820 | — | — | 1 | 8.74 |
| CHEMBL418258 | — | — | 1 | 8.68 |
| CHEMBL297081 | — | — | 1 | 8.66 |
| CHEMBL47089 | — | — | 1 | 8.54 |
| CHEMBL47041 | — | — | 1 | 8.15 |
| CHEMBL45424 | — | — | 1 | 8.07 |
| CHEMBL288569 | — | — | 1 | 7.94 |
| CHEMBL296195 | — | — | 1 | 7.64 |
| CHEMBL176768 | — | — | 1 | 7.55 |
| CHEMBL415909 | — | — | 1 | 7.40 |
| CHEMBL291187 | — | — | 1 | 7.00 |
| CHEMBL44996 | — | — | 1 | 6.70 |
| CHEMBL297987 | — | — | 1 | 6.70 |
| CHEMBL46739 | — | — | 1 | 6.62 |
| CHEMBL46502 | — | — | 1 | 6.58 |
| CHEMBL44535 | — | — | 1 | 6.52 |
| CHEMBL296690 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45114 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL288683 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL432111 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL44047 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL46821 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL290528 | — | IC50 | = | 0.93 | nM | 9.03 |
| CHEMBL42459 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL46884 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL47094 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL46633 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL295657 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL289560 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL42389 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL42820 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL418258 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL297081 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL47089 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL47041 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL45424 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL288569 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL296195 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL176768 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL415909 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL291187 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL44996 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL297987 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL46739 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL46502 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL44535 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL296690 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL43963 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL417528 | — | IC50 | = | 1650.0 | nM | 5.78 |