Assay Detail
Functional
CHEMBL873899
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Ability to inhibit [3H]anandamide uptake in human lymphoma U937 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.22 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434778 | — | — | 1 | 6.10 |
| CHEMBL284300 | — | — | 1 | 5.52 |
| CHEMBL39878 | — | — | 1 | 5.40 |
| CHEMBL39460 | — | — | 1 | 5.30 |
| CHEMBL417158 | — | — | 1 | 5.30 |
| CHEMBL431128 | — | — | 1 | 5.24 |
| CHEMBL287130 | — | — | 1 | 5.10 |
| CHEMBL290716 | — | — | 1 | 4.85 |
| CHEMBL287364 | — | — | 1 | 4.75 |
| CHEMBL38293 | — | — | 1 | 4.62 |
| CHEMBL287788 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434778 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL284300 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL39878 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL39460 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL417158 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL431128 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL287130 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL290716 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL287364 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL38293 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL287788 | — | IC50 | = | - | nM | - |