Assay Detail
Binding
CHEMBL873902
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant tumor necrosis factor-alpha converting enzyme.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3706) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological activity of piperazine-based dual MMP-13 and TNF-alpha converting enzyme inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.84 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL110211 | — | — | 1 | 8.30 |
| CHEMBL110901 | — | — | 1 | 8.22 |
| CHEMBL111862 | — | — | 1 | 8.22 |
| CHEMBL110591 | — | — | 1 | 8.22 |
| CHEMBL110576 | — | — | 1 | 8.22 |
| CHEMBL263054 | — | — | 1 | 8.15 |
| CHEMBL109775 | — | — | 1 | 8.15 |
| CHEMBL281920 | — | — | 1 | 8.05 |
| CHEMBL278060 | — | — | 1 | 7.96 |
| CHEMBL322476 | — | — | 1 | 7.96 |
| CHEMBL95807 | — | — | 1 | 7.89 |
| CHEMBL326221 | — | — | 1 | 7.85 |
| CHEMBL112232 | — | — | 1 | 7.72 |
| CHEMBL109833 | — | — | 1 | 7.60 |
| CHEMBL110994 | — | — | 1 | 7.58 |
| CHEMBL109267 | — | — | 1 | 7.55 |
| CHEMBL322705 | — | — | 1 | 7.51 |
| CHEMBL111460 | — | — | 1 | 7.50 |
| CHEMBL111068 | — | — | 1 | 7.47 |
| CHEMBL111262 | — | — | 1 | 7.40 |
| CHEMBL325150 | — | — | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL110211 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL110901 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL111862 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL110591 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL110576 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL263054 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL109775 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL281920 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL278060 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL322476 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL95807 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL326221 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL112232 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL109833 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL110994 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL109267 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL322705 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL111460 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL111068 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL111262 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL325150 | — | IC50 | = | 68.0 | nM | 7.17 |