Assay Detail
Binding
CHEMBL873905
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In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (CHEMBL1787) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Nonsteroidal inhibitors of human type I steroid 5-alpha-reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.51 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24955 | BEXLOSTERIDE | 2.0 | 1 | 8.10 |
| CHEMBL134357 | — | — | 1 | 7.96 |
| CHEMBL29166 | — | — | 1 | 7.77 |
| CHEMBL16456 | — | — | 1 | 7.52 |
| CHEMBL424084 | — | — | 1 | 7.46 |
| CHEMBL281204 | — | — | 1 | 7.39 |
| CHEMBL134810 | — | — | 1 | 7.22 |
| CHEMBL335919 | — | — | 1 | 6.92 |
| CHEMBL135014 | — | — | 1 | 6.92 |
| CHEMBL131803 | — | — | 1 | 6.50 |
| CHEMBL277664 | — | — | 1 | 6.34 |
| CHEMBL57789 | — | — | 1 | 6.25 |
| CHEMBL134114 | — | — | 1 | 6.22 |
| CHEMBL336854 | — | — | 1 | 5.75 |
| CHEMBL132086 | — | — | 1 | 5.64 |
| CHEMBL441287 | — | — | 1 | 5.50 |
| CHEMBL134819 | — | — | 1 | 5.44 |
| CHEMBL27549 | — | — | 1 | 5.19 |
| CHEMBL138225 | EPRISTERIDE | 2.0 | 1 | 5.12 |
| CHEMBL336200 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24955 | BEXLOSTERIDE | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL134357 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL29166 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL16456 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL424084 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL281204 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL134810 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL335919 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL135014 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL131803 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL277664 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL57789 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL134114 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL336854 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL132086 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL441287 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL134819 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL27549 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL138225 | EPRISTERIDE | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL336200 | — | IC50 | = | 10000.0 | nM | 5.00 |