Assay Detail
Functional
CHEMBL873906
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine tubulin polymerization
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Intermediate |
Publication
Antitumor agents. 155. Synthesis and biological evaluation of 3',6,7-substituted 2-phenyl-4-quinolones as antimicrotubule agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.07 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50826 | — | — | 1 | 6.44 |
| CHEMBL50809 | — | — | 1 | 6.43 |
| CHEMBL301589 | — | — | 1 | 6.42 |
| CHEMBL15778 | — | — | 1 | 6.36 |
| CHEMBL325260 | — | — | 1 | 6.35 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 6.34 |
| CHEMBL114883 | — | — | 1 | 6.33 |
| CHEMBL299143 | — | — | 1 | 6.33 |
| CHEMBL117993 | — | — | 1 | 6.30 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.28 |
| CHEMBL117994 | — | — | 1 | 6.28 |
| CHEMBL48961 | — | — | 1 | 6.28 |
| CHEMBL279142 | — | — | 1 | 6.24 |
| CHEMBL418350 | — | — | 1 | 6.20 |
| CHEMBL10557 | — | — | 1 | 6.20 |
| CHEMBL49559 | — | — | 1 | 6.19 |
| CHEMBL113928 | — | — | 1 | 6.16 |
| CHEMBL275872 | — | — | 1 | 6.16 |
| CHEMBL114849 | — | — | 1 | 6.14 |
| CHEMBL299305 | — | — | 1 | 6.14 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 6.10 |
| CHEMBL50227 | — | — | 1 | 6.09 |
| CHEMBL115022 | — | — | 1 | 5.82 |
| CHEMBL325681 | — | — | 1 | 5.68 |
| CHEMBL114661 | — | — | 1 | 5.64 |
| CHEMBL420676 | — | — | 1 | 5.21 |
| CHEMBL326527 | — | — | 1 | 5.06 |
| CHEMBL114784 | — | — | 1 | 4.85 |
| CHEMBL114789 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50826 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL50809 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL301589 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL15778 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL325260 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL61 | PODOFILOX | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL114883 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL299143 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL117993 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL117994 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL48961 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL279142 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL418350 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL10557 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL49559 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL113928 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL275872 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL114849 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL299305 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL107 | COLCHICINE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL50227 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL115022 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL325681 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL114661 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL420676 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL326527 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL114784 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL114789 | — | IC50 | > | 40000.0 | nM | - |