Assay Detail
Binding
CHEMBL873913
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The compound was evaluated for binding affinity against Opioid receptor delta 1 in guinea pig brain membrane using [3H]- DPDPE as ligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Opioid agonist and antagonist activities of morphindoles related to naltrindole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.97 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | — | 1 | 10.52 |
| CHEMBL401093 | OXYMORPHINDOLE | — | 1 | 9.15 |
| CHEMBL607393 | — | — | 1 | 7.96 |
| CHEMBL285563 | — | — | 1 | 7.96 |
| CHEMBL607339 | — | — | 1 | 7.66 |
| CHEMBL47545 | — | — | 1 | 7.46 |
| CHEMBL607395 | — | — | 1 | 6.98 |
| CHEMBL344000 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL401093 | OXYMORPHINDOLE | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL607393 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL285563 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL607339 | — | Ki | = | 21.9 | nM | 7.66 |
| CHEMBL47545 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL607395 | — | Ki | = | 105.7 | nM | 6.98 |
| CHEMBL344000 | — | Ki | = | 935.0 | nM | 6.03 |