Assay Detail
Binding
CHEMBL873934
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Ability to inhibit the matrix metalloprotease-2 by method of Knight et al using the fluorogenic peptide substrate.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Selectivity of inhibition of matrix metalloproteases MMP-3 and MMP-2 by succinyl hydroxamates and their carboxylic acid analogues is dependent on P3' group chirality.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.46 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL347595 | — | — | 1 | 9.70 |
| CHEMBL20154 | — | — | 1 | 9.47 |
| CHEMBL153914 | — | — | 1 | 9.42 |
| CHEMBL279786 | BATIMASTAT | 2.0 | 1 | 9.30 |
| CHEMBL154317 | — | — | 1 | 9.00 |
| CHEMBL157112 | — | — | 1 | 8.89 |
| CHEMBL350231 | — | — | 1 | 8.80 |
| CHEMBL421985 | — | — | 1 | 8.48 |
| CHEMBL152855 | — | — | 1 | 8.47 |
| CHEMBL152592 | — | — | 1 | 8.24 |
| CHEMBL345445 | — | — | 1 | 8.19 |
| CHEMBL152805 | — | — | 1 | 7.96 |
| CHEMBL152531 | — | — | 1 | 7.82 |
| CHEMBL152267 | — | — | 1 | 7.58 |
| CHEMBL152625 | — | — | 1 | 7.52 |
| CHEMBL154215 | — | — | 1 | 7.42 |
| CHEMBL349099 | — | — | 1 | 7.30 |
| CHEMBL152769 | — | — | 1 | 7.27 |
| CHEMBL154551 | — | — | 1 | 7.21 |
| CHEMBL157163 | — | — | 1 | 7.21 |
| CHEMBL157048 | — | — | 1 | 7.08 |
| CHEMBL153446 | — | — | 1 | 6.96 |
| CHEMBL349124 | — | — | 1 | 6.57 |
| CHEMBL345818 | — | — | 1 | 6.55 |
| CHEMBL414626 | — | — | 1 | 6.48 |
| CHEMBL436230 | — | — | 1 | 6.38 |
| CHEMBL156614 | — | — | 1 | 6.11 |
| CHEMBL541456 | — | — | 1 | 5.80 |
| CHEMBL268992 | — | — | 1 | 5.61 |
| CHEMBL347594 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL347595 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL20154 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL153914 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL279786 | BATIMASTAT | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL154317 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL157112 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL350231 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL421985 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL152855 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL152592 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL345445 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL152805 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL152531 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL152267 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL152625 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL154215 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL349099 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL152769 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL154551 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL157163 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL157048 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL153446 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL349124 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL345818 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL414626 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL436230 | — | IC50 | = | 414.0 | nM | 6.38 |
| CHEMBL156614 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL541456 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL268992 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL347594 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL433934 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL156663 | — | IC50 | = | 6200.0 | nM | 5.21 |