Assay Detail
Binding
CHEMBL874055
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In vitro inhibition of prolyl oligopeptidase (POP) from pig brain
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
New prolyl oligopeptidase inhibitors developed from dicarboxylic acid bis(l-prolyl-pyrrolidine) amides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.97 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL435223 | — | — | 1 | 9.49 |
| CHEMBL141588 | — | — | 1 | 9.41 |
| CHEMBL343570 | — | — | 1 | 9.24 |
| CHEMBL139552 | — | — | 1 | 9.21 |
| CHEMBL341691 | — | — | 1 | 9.14 |
| CHEMBL138361 | — | — | 1 | 8.96 |
| CHEMBL344247 | — | — | 1 | 8.92 |
| CHEMBL335815 | — | — | 1 | 8.89 |
| CHEMBL408666 | — | — | 1 | 8.89 |
| CHEMBL140461 | — | — | 1 | 8.82 |
| CHEMBL138334 | — | — | 1 | 8.80 |
| CHEMBL138635 | — | — | 1 | 8.38 |
| CHEMBL140623 | — | — | 1 | 7.89 |
| CHEMBL138550 | — | — | 1 | 7.85 |
| CHEMBL138367 | — | — | 1 | 7.75 |
| CHEMBL141416 | — | — | 1 | 7.64 |
| CHEMBL141158 | — | — | 1 | 7.58 |
| CHEMBL141787 | — | — | 1 | 7.51 |
| CHEMBL140687 | — | — | 1 | 7.48 |
| CHEMBL140310 | — | — | 1 | 7.41 |
| CHEMBL335354 | — | — | 1 | 7.27 |
| CHEMBL138978 | — | — | 1 | 7.19 |
| CHEMBL140059 | — | — | 1 | 7.11 |
| CHEMBL344019 | — | — | 1 | 7.09 |
| CHEMBL142133 | — | — | 1 | 7.06 |
| CHEMBL141728 | — | — | 1 | 6.96 |
| CHEMBL343361 | — | — | 1 | 6.77 |
| CHEMBL140595 | — | — | 1 | 6.19 |
| CHEMBL139617 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL435223 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL141588 | — | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL343570 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL139552 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL341691 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL138361 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL344247 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL335815 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL408666 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL140461 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL138334 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL138635 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL140623 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL138550 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL138367 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL141416 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL141158 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL141787 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL140687 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL140310 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL335354 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL138978 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL140059 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL344019 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL142133 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL141728 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL343361 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL140595 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL139617 | — | IC50 | = | 640.0 | nM | 6.19 |