Assay Detail
Binding
CHEMBL874091
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Inhibitory conc. against Vesicular glutamate transporter (VGLUT), derived from Lineweaver-Burke analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Vesicular glutamate transporter 3 (CHEMBL3472) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and in vitro pharmacology of substituted quinoline-2,4-dicarboxylic acids as inhibitors of vesicular glutamate transport.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 4.02 | 4.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL312117 | — | — | 1 | 4.02 |
| CHEMBL73304 | — | — | 1 | - |
| CHEMBL76124 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL312117 | — | Ki | = | 95000.0 | nM | 4.02 |
| CHEMBL73304 | — | Ki | = | 204000.0 | nM | - |
| CHEMBL76124 | — | Ki | = | 129000.0 | nM | - |