Assay Detail
Binding
CHEMBL874093
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Inhibitory compound against Wild-type human DHFR.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.51 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL164845 | — | — | 1 | 8.27 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 7.89 |
| CHEMBL341703 | — | — | 1 | 7.64 |
| CHEMBL349149 | — | — | 1 | 7.39 |
| CHEMBL441298 | — | — | 1 | 7.14 |
| CHEMBL350730 | — | — | 1 | 6.70 |
| CHEMBL162312 | — | — | 1 | - |
| CHEMBL434097 | — | — | 1 | - |
| CHEMBL162270 | — | — | 1 | - |
| CHEMBL165955 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL164845 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL119 | TRIMETREXATE | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL341703 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL349149 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL441298 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL350730 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL162312 | — | Ki | > | 500.0 | nM | - |
| CHEMBL434097 | — | Ki | > | 500.0 | nM | - |
| CHEMBL162270 | — | Ki | > | 500.0 | nM | - |
| CHEMBL165955 | — | Ki | > | 500.0 | nM | - |