Assay Detail
Binding
CHEMBL874100
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Binding affinity for Plasmodium falciparum plasmepsin-1.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design and synthesis of plasmepsin I and plasmepsin II inhibitors with activity in Plasmodium falciparum-infected cultured human erythrocytes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.44 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL162554 | — | — | 1 | 7.20 |
| CHEMBL353118 | — | — | 1 | 7.17 |
| CHEMBL163249 | — | — | 1 | 7.01 |
| CHEMBL163104 | — | — | 1 | 6.94 |
| CHEMBL349737 | — | — | 1 | 6.36 |
| CHEMBL162898 | — | — | 1 | 6.33 |
| CHEMBL162454 | — | — | 1 | 6.28 |
| CHEMBL434853 | — | — | 1 | 6.00 |
| CHEMBL162495 | — | — | 1 | 5.96 |
| CHEMBL349736 | — | — | 1 | 5.89 |
| CHEMBL351939 | — | — | 1 | 5.69 |
| CHEMBL349421 | — | — | 1 | - |
| CHEMBL436438 | — | — | 1 | - |
| CHEMBL163085 | — | — | 1 | - |
| CHEMBL162362 | — | — | 1 | - |
| CHEMBL350081 | — | — | 1 | - |
| CHEMBL353782 | — | — | 1 | - |
| CHEMBL163038 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL162554 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL353118 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL163249 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL163104 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL349737 | — | Ki | = | 437.0 | nM | 6.36 |
| CHEMBL162898 | — | Ki | = | 469.0 | nM | 6.33 |
| CHEMBL162454 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL434853 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL162495 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL349736 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL351939 | — | Ki | = | 2046.0 | nM | 5.69 |
| CHEMBL349421 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL436438 | — | Ki | ~ | 2900.0 | nM | - |
| CHEMBL163085 | — | Ki | ~ | 8000.0 | nM | - |
| CHEMBL162362 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL350081 | — | Ki | ~ | 2100.0 | nM | - |
| CHEMBL353782 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL163038 | — | Ki | > | 2000.0 | nM | - |