Assay Detail
Functional
CHEMBL874150
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Inhibition of transport of [3H]spermidine in L1210 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of hydroxylated polyamine analogues as antiproliferatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.90 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77818 | — | — | 1 | 5.17 |
| CHEMBL44083 | BIS(ETHYL)NORSPERMINE | — | 1 | 5.16 |
| CHEMBL33387 | — | — | 1 | 4.89 |
| CHEMBL77102 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77818 | — | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL44083 | BIS(ETHYL)NORSPERMINE | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL33387 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL77102 | — | Ki | = | 43000.0 | nM | 4.37 |