Assay Detail
Functional
CHEMBL874158
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxic activity against cellular metabolic activity of Lung NCI-H460 tumor cell line using XTT proliferation assay after incubation with the compound for 48 h
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.27 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.00 |
| CHEMBL112192 | — | — | 1 | 7.22 |
| CHEMBL116173 | — | — | 1 | 7.16 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.16 |
| CHEMBL9514 | NOCODAZOLE | 2.0 | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL112192 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL116173 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL107 | COLCHICINE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL9514 | NOCODAZOLE | IC50 | = | 150.0 | nM | 6.82 |