Assay Detail
Functional
CHEMBL874174
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Inhibition of estradiol-stimulated MCF-7 breast adenocarcinoma cell proliferation
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Tetrahydroquinoline-based selective estrogen receptor modulators (SERMs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.88 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 9.70 |
| CHEMBL2137046 | — | — | 1 | 8.59 |
| CHEMBL56306 | — | — | 1 | 7.17 |
| CHEMBL56198 | — | — | 1 | 6.57 |
| CHEMBL58688 | — | — | 1 | 6.41 |
| CHEMBL60538 | — | — | 1 | 6.31 |
| CHEMBL56390 | — | — | 1 | 6.31 |
| CHEMBL59311 | — | — | 1 | 6.23 |
| CHEMBL293297 | — | — | 1 | 6.23 |
| CHEMBL59146 | — | — | 1 | 6.21 |
| CHEMBL56166 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81 | RALOXIFENE | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL2137046 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL56306 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL56198 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL58688 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL60538 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL56390 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL59311 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL293297 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL59146 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL56166 | — | IC50 | = | 990.0 | nM | 6.00 |