Assay Detail
Functional
CHEMBL874217
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Effect on the increase in cAMP formation induced by PGD-2 in the presence of bovine serum albumin in CHO cells expressing human Prostaglandin D2 receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of orally active prostaglandin D2 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.67 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185251 | — | — | 1 | 9.09 |
| CHEMBL364841 | — | — | 1 | 8.92 |
| CHEMBL365696 | — | — | 1 | 8.00 |
| CHEMBL364593 | — | — | 1 | 7.52 |
| CHEMBL363984 | — | — | 1 | 7.52 |
| CHEMBL365829 | — | — | 1 | 7.52 |
| CHEMBL184684 | — | — | 1 | 7.30 |
| CHEMBL186735 | — | — | 1 | 6.60 |
| CHEMBL365908 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185251 | — | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL364841 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL365696 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL364593 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL363984 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL365829 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL184684 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL186735 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL365908 | — | IC50 | = | 270.0 | nM | 6.57 |