Assay Detail
Binding
CHEMBL874429
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Inhibition of recombinant human Chk2 kinase
48
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Serine/threonine-protein kinase Chk2 (CHEMBL2527) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 7.10 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL195041 | — | — | 1 | 8.64 |
| CHEMBL195177 | — | — | 1 | 8.47 |
| CHEMBL359881 | — | — | 1 | 8.36 |
| CHEMBL179717 | — | — | 1 | 8.35 |
| CHEMBL175553 | — | — | 1 | 8.26 |
| CHEMBL193990 | — | — | 1 | 8.18 |
| CHEMBL191969 | — | — | 1 | 8.09 |
| CHEMBL175472 | — | — | 1 | 8.01 |
| CHEMBL369254 | — | — | 1 | 7.92 |
| CHEMBL362255 | — | — | 1 | 7.92 |
| CHEMBL361378 | — | — | 1 | 7.92 |
| CHEMBL364978 | — | — | 1 | 7.89 |
| CHEMBL195846 | — | — | 1 | 7.85 |
| CHEMBL179583 | — | — | 2 | 7.82 |
| CHEMBL178972 | — | — | 1 | 7.77 |
| CHEMBL195320 | — | — | 1 | 7.75 |
| CHEMBL176164 | — | — | 1 | 7.64 |
| CHEMBL175879 | — | — | 1 | 7.62 |
| CHEMBL179267 | — | — | 1 | 7.51 |
| CHEMBL192022 | — | — | 1 | 7.50 |
| CHEMBL363339 | — | — | 1 | 7.39 |
| CHEMBL362677 | — | — | 1 | 7.33 |
| CHEMBL178971 | — | — | 1 | 7.26 |
| CHEMBL367263 | — | — | 1 | 7.21 |
| CHEMBL193397 | — | — | 1 | 7.09 |
| CHEMBL193476 | — | — | 1 | 7.00 |
| CHEMBL176326 | — | — | 1 | 6.70 |
| CHEMBL175780 | — | — | 1 | 6.70 |
| CHEMBL195599 | — | — | 1 | 6.60 |
| CHEMBL176015 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL195041 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL195177 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL359881 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL179717 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL175553 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL193990 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL191969 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL175472 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL369254 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL362255 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL361378 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL364978 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL195846 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL179583 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL179583 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL178972 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL195320 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL176164 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL175879 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL179267 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL192022 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL363339 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL362677 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL178971 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL367263 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL193397 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL193476 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL175780 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL176326 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL195599 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL176015 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL193394 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL195648 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL175676 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL367390 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL195598 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL381436 | — | IC50 | = | 715.0 | nM | 6.15 |
| CHEMBL195678 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL176235 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL176115 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL176041 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL179636 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL175481 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL176554 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL179383 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL176276 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL192156 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL175878 | — | IC50 | > | 10000.0 | nM | - |