Assay Detail
Binding
CHEMBL874513
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Inhibition of cathepsin B
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Benzoylalanine-derived ketoamides carrying vinylbenzyl amino residues: discovery of potent water-soluble calpain inhibitors with oral bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.32 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423112 | — | — | 1 | 7.75 |
| CHEMBL77784 | — | — | 1 | 7.57 |
| CHEMBL80605 | — | — | 1 | 7.21 |
| CHEMBL80933 | — | — | 1 | 7.08 |
| CHEMBL310855 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423112 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL77784 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL80605 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL80933 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL310855 | — | Ki | = | 99.0 | nM | 7.00 |