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Assay Detail

CHEMBL874550

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Binding
Inhibitory concentration required against human GLP1 receptor expressed in CHO cell membrane homogenates
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Expert

Target

Glucagon-like peptide 1 receptor (CHEMBL1784)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification of CJC-1131-albumin bioconjugate as a stable and bioactive GLP-1(7-36) analog.
Léger R, Thibaudeau K, Robitaille M, Quraishi O, van Wyk P, Bousquet-Gagnon N, Carette J, Castaigne JP, Bridon DP.
Bioorg Med Chem Lett (2004) 14 : 4395 -4398
PubMed 15357960 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 6.53 7.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL410972 1 7.85
CHEMBL2371792 1 7.06
CHEMBL2371793 1 6.97
CHEMBL412288 1 6.53
CHEMBL409873 1 6.34
CHEMBL439104 1 6.15
CHEMBL410973 1 6.09
CHEMBL265428 1 5.27
CHEMBL409371 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL410972 IC50 = 14.0 nM 7.85
CHEMBL2371792 IC50 = 87.0 nM 7.06
CHEMBL2371793 IC50 = 108.0 nM 6.97
CHEMBL412288 IC50 = 296.0 nM 6.53
CHEMBL409873 IC50 = 454.0 nM 6.34
CHEMBL439104 IC50 = 713.0 nM 6.15
CHEMBL410973 IC50 = 804.0 nM 6.09
CHEMBL265428 IC50 = 5354.0 nM 5.27
CHEMBL409371 IC50 > 10000.0 nM -