Assay Detail
Binding
CHEMBL874564
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Concentration required to inhibit in vitro RNA-dependent DNA polymerase activity of reverse transcriptase
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.83 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL393003 | — | — | 1 | 5.54 |
| CHEMBL370921 | — | — | 1 | 5.28 |
| CHEMBL192976 | — | — | 1 | 5.12 |
| CHEMBL362924 | — | — | 1 | 4.90 |
| CHEMBL192499 | — | — | 1 | 4.79 |
| CHEMBL192310 | — | — | 1 | 4.70 |
| CHEMBL53554 | THIAZOLOBENZIMIDAZOLE | — | 1 | 4.61 |
| CHEMBL366202 | — | — | 1 | 4.30 |
| CHEMBL191692 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL393003 | — | IC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL370921 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL192976 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL362924 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL192499 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL192310 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL53554 | THIAZOLOBENZIMIDAZOLE | IC50 | = | 24570.0 | nM | 4.61 |
| CHEMBL366202 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL191692 | — | IC50 | = | 60000.0 | nM | 4.22 |