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Assay Detail

CHEMBL874858

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Cyclin-dependent kinase 2 enzyme from starfish oocytes
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Marthasterias glacialis
Cell Type Oocyte
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Cyclin-dependent kinase 2 (CHEMBL301)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles.
Arris CE, Boyle FT, Calvert AH, Curtin NJ, Endicott JA, Garman EF, Gibson AE, Golding BT, Grant S, Griffin RJ, Jewsbury P, Johnson LN, Lawrie AM, Newell DR, Noble ME, Sausville EA, Schultz R, Yu W.
J Med Chem (2000) 43 : 2797 -2804
PubMed 10956187 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 4.92 4.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL269881 1 4.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL269881 Ki = 12000.0 nM 4.92