Assay Detail
Functional
CHEMBL874945
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In vitro inhibitory concentration is measured by the incorporation of [14C]thymidine in human breast carcinoma MDA-MB-435 cell line
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-435 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pyrido[2,3-d]pyrimidin-7-ones as specific inhibitors of cyclin-dependent kinase 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.84 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365847 | — | — | 1 | 7.50 |
| CHEMBL190096 | — | — | 1 | 6.77 |
| CHEMBL426818 | — | — | 1 | 6.72 |
| CHEMBL192945 | — | — | 1 | 6.37 |
| CHEMBL192641 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365847 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL190096 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL426818 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL192945 | — | IC50 | = | 425.0 | nM | 6.37 |
| CHEMBL192641 | — | IC50 | > | 3000.0 | nM | - |