Assay Detail
Functional
CHEMBL874953
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 100 nM NECA-stimulated cAMP production in CHO cells expressing human adenosine A2B receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New pyrrolo[2,1-f]purine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives as potent and selective human A3 adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.40 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189904 | — | — | 1 | 6.40 |
| CHEMBL371404 | — | — | 1 | - |
| CHEMBL193130 | — | — | 1 | - |
| CHEMBL434534 | — | — | 1 | - |
| CHEMBL372026 | — | — | 1 | - |
| CHEMBL188269 | — | — | 1 | - |
| CHEMBL191421 | — | — | 1 | - |
| CHEMBL364036 | — | — | 1 | - |
| CHEMBL191414 | — | — | 1 | - |
| CHEMBL188506 | — | — | 1 | - |
| CHEMBL373090 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189904 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL371404 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL193130 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL434534 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL372026 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL188269 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL191421 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL364036 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL191414 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL188506 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL373090 | — | IC50 | > | 1000.0 | nM | - |