Assay Detail
Functional
CHEMBL874972
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells expressing GnRH receptor
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Gonadotropin-releasing hormone receptor (CHEMBL1855) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of neutral 4-O-alkyl quinolone nonpeptide GnRH receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 8.15 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL364167 | — | — | 1 | 9.15 |
| CHEMBL362371 | — | — | 1 | 9.10 |
| CHEMBL120432 | — | — | 1 | 9.05 |
| CHEMBL441676 | — | — | 1 | 8.89 |
| CHEMBL433594 | — | — | 1 | 8.80 |
| CHEMBL48192 | — | — | 1 | 8.66 |
| CHEMBL362544 | — | — | 1 | 8.66 |
| CHEMBL184819 | — | — | 1 | 8.48 |
| CHEMBL185986 | — | — | 1 | 8.24 |
| CHEMBL185738 | — | — | 1 | 7.96 |
| CHEMBL360429 | — | — | 1 | 7.75 |
| CHEMBL365366 | — | — | 1 | 7.75 |
| CHEMBL424991 | — | — | 1 | 7.50 |
| CHEMBL363663 | — | — | 1 | 7.31 |
| CHEMBL185785 | — | — | 1 | 7.17 |
| CHEMBL185438 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL364167 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL362371 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL120432 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL441676 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL433594 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL48192 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL362544 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL184819 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL185986 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL185738 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL360429 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL365366 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL424991 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL363663 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL185785 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL185438 | — | IC50 | = | 1150.0 | nM | 5.94 |