Assay Detail
Binding
CHEMBL875082
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Binding affinity was determined against cloned 5-hydroxytryptamine 4B receptor isoform expressed in COS-7 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | COS-7 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New arylpiperazine derivatives as antagonists of the human cloned 5-HT(4) receptor isoforms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.15 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33884 | — | — | 1 | 9.28 |
| CHEMBL121913 | — | — | 1 | 8.09 |
| CHEMBL286136 | — | — | 1 | 7.97 |
| CHEMBL123377 | — | — | 1 | 7.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33884 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL121913 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL286136 | — | Ki | = | 10.7 | nM | 7.97 |
| CHEMBL123377 | — | Ki | = | 55.0 | nM | 7.26 |