Assay Detail
Binding
CHEMBL875087
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for inhibitory activity against 5-lipoxygenase in human polymorphonuclear leukocytes[PMNS]
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.44 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310584 | — | — | 1 | 7.70 |
| CHEMBL314449 | — | — | 1 | 6.10 |
| CHEMBL274642 | BW-755C | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310584 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL314449 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL274642 | BW-755C | IC50 | = | 3000.0 | nM | 5.52 |