Assay Detail
Binding
CHEMBL875101
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | COS-7 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New tetrahydrobenzindoles as potent and selective 5-HT(7) antagonists with increased In vitro metabolic stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.45 | 8.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422869 | — | — | 1 | 8.69 |
| CHEMBL69257 | — | — | 1 | 8.67 |
| CHEMBL418888 | — | — | 1 | 8.45 |
| CHEMBL348410 | — | — | 1 | 8.30 |
| CHEMBL348890 | — | — | 1 | 8.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422869 | — | Ki | = | 2.042 | nM | 8.69 |
| CHEMBL69257 | — | Ki | = | 2.138 | nM | 8.67 |
| CHEMBL418888 | — | Ki | = | 3.548 | nM | 8.45 |
| CHEMBL348410 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL348890 | — | Ki | = | 7.244 | nM | 8.14 |