Assay Detail
Functional
CHEMBL875115
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against proliferation of MCF-7 (ER Positive) breast cancer cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological evaluation of biotin conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid for the isolation of the protein targets.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.37 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1762621 | BARDOXOLONE METHYL | 3.0 | 1 | 7.30 |
| CHEMBL186639 | — | — | 1 | 7.10 |
| CHEMBL1093059 | BARDOXOLONE | 2.0 | 1 | 6.80 |
| CHEMBL183308 | — | — | 1 | 6.26 |
| CHEMBL189340 | — | — | 1 | 5.48 |
| CHEMBL362749 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1762621 | BARDOXOLONE METHYL | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL186639 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1093059 | BARDOXOLONE | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL183308 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL189340 | — | IC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL362749 | — | IC50 | = | 5260.0 | nM | 5.28 |