Assay Detail
Binding
CHEMBL875193
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory constant against human tumor Carbonic anhydrases IX or XII
30
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 5.20 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169486 | — | — | 2 | 7.72 |
| CHEMBL166340 | — | — | 2 | 7.52 |
| CHEMBL167179 | — | — | 2 | 4.58 |
| CHEMBL168910 | — | — | 2 | 4.52 |
| CHEMBL68536 | PERFLUOROPHENYL SULFAMATE | — | 2 | 4.47 |
| CHEMBL67749 | — | — | 2 | 4.40 |
| CHEMBL24119 | — | — | 2 | 4.39 |
| CHEMBL303601 | — | — | 2 | 4.27 |
| CHEMBL355001 | SULFAMIDE | — | 2 | - |
| CHEMBL305268 | METHANESULFONAMIDE | — | 2 | - |
| CHEMBL195540 | — | — | 2 | - |
| CHEMBL193635 | — | — | 2 | - |
| CHEMBL195370 | — | — | 2 | - |
| CHEMBL193396 | — | — | 2 | - |
| CHEMBL370104 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169486 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL166340 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL169486 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL166340 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL167179 | — | Ki | = | 26000.0 | nM | 4.58 |
| CHEMBL168910 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL68536 | PERFLUOROPHENYL SULFAMATE | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL168910 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL67749 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL24119 | — | Ki | = | 41000.0 | nM | 4.39 |
| CHEMBL68536 | PERFLUOROPHENYL SULFAMATE | Ki | = | 47000.0 | nM | 4.33 |
| CHEMBL167179 | — | Ki | = | 48000.0 | nM | 4.32 |
| CHEMBL303601 | — | Ki | = | 54000.0 | nM | 4.27 |
| CHEMBL67749 | — | Ki | = | 62000.0 | nM | 4.21 |
| CHEMBL24119 | — | Ki | = | 76000.0 | nM | 4.12 |
| CHEMBL355001 | SULFAMIDE | Ki | = | 9600000.0 | nM | - |
| CHEMBL355001 | SULFAMIDE | Ki | = | 13200000.0 | nM | - |
| CHEMBL305268 | METHANESULFONAMIDE | Ki | = | 9200000.0 | nM | - |
| CHEMBL305268 | METHANESULFONAMIDE | Ki | = | 10700000.0 | nM | - |
| CHEMBL195540 | — | Ki | = | 865000.0 | nM | - |
| CHEMBL195540 | — | Ki | = | 1340000.0 | nM | - |
| CHEMBL193635 | — | Ki | = | 506000.0 | nM | - |
| CHEMBL193635 | — | Ki | = | 874000.0 | nM | - |
| CHEMBL195370 | — | Ki | = | 485000.0 | nM | - |
| CHEMBL195370 | — | Ki | = | 539000.0 | nM | - |
| CHEMBL193396 | — | Ki | = | 790000.0 | nM | - |
| CHEMBL303601 | — | Ki | = | 103000.0 | nM | - |
| CHEMBL193396 | — | Ki | = | 633000.0 | nM | - |
| CHEMBL370104 | — | Ki | = | 353000.0 | nM | - |
| CHEMBL370104 | — | Ki | = | 372000.0 | nM | - |