Assay Detail
Binding
CHEMBL875209
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Inhibitory constant against human thymidylate synthase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.57 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL179448 | — | — | 1 | 8.82 |
| CHEMBL362606 | — | — | 1 | 8.39 |
| CHEMBL360335 | — | — | 1 | 8.07 |
| CHEMBL425692 | — | — | 1 | 7.96 |
| CHEMBL360758 | — | — | 1 | 7.89 |
| CHEMBL176072 | — | — | 1 | 4.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL179448 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL362606 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL360335 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL425692 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL360758 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL176072 | — | Ki | = | 49000.0 | nM | 4.31 |