Assay Detail
Binding
CHEMBL875212
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Inhibitory concentration against the human Cathepsin D
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.01 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191130 | — | — | 1 | 9.15 |
| CHEMBL371417 | — | — | 1 | 8.80 |
| CHEMBL264770 | — | — | 1 | 8.60 |
| CHEMBL191260 | — | — | 1 | 8.49 |
| CHEMBL363286 | — | — | 1 | 8.41 |
| CHEMBL112598 | — | — | 1 | 8.31 |
| CHEMBL113208 | — | — | 1 | 7.68 |
| CHEMBL190290 | — | — | 1 | 7.50 |
| CHEMBL33989 | — | — | 1 | 7.20 |
| CHEMBL370086 | — | — | 1 | 6.62 |
| CHEMBL114278 | — | — | 1 | 6.33 |
| CHEMBL364630 | — | — | 1 | 6.32 |
| CHEMBL371182 | — | — | 1 | 6.16 |
| CHEMBL371082 | — | — | 1 | 5.84 |
| CHEMBL365935 | — | — | 1 | 5.76 |
| CHEMBL190539 | — | — | 1 | 5.73 |
| CHEMBL189976 | — | — | 1 | 5.57 |
| CHEMBL363692 | — | — | 1 | 5.44 |
| CHEMBL191487 | — | — | 1 | 5.31 |
| CHEMBL322979 | — | — | 1 | - |
| CHEMBL190348 | — | — | 1 | - |
| CHEMBL111720 | — | — | 1 | - |
| CHEMBL113331 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191130 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL371417 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL264770 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL191260 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL363286 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL112598 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL113208 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL190290 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL33989 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL370086 | — | Ki | = | 241.0 | nM | 6.62 |
| CHEMBL114278 | — | Ki | = | 473.0 | nM | 6.33 |
| CHEMBL364630 | — | Ki | = | 481.0 | nM | 6.32 |
| CHEMBL371182 | — | Ki | = | 685.0 | nM | 6.16 |
| CHEMBL371082 | — | Ki | = | 1440.0 | nM | 5.84 |
| CHEMBL365935 | — | Ki | = | 1730.0 | nM | 5.76 |
| CHEMBL190539 | — | Ki | = | 1880.0 | nM | 5.73 |
| CHEMBL189976 | — | Ki | = | 2701.0 | nM | 5.57 |
| CHEMBL363692 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL191487 | — | Ki | = | 4940.0 | nM | 5.31 |
| CHEMBL322979 | — | Ki | > | 5900.0 | nM | - |
| CHEMBL190348 | — | Ki | > | 5900.0 | nM | - |
| CHEMBL111720 | — | Ki | > | 5900.0 | nM | - |
| CHEMBL113331 | — | Ki | > | 4000.0 | nM | - |