Assay Detail
Binding
CHEMBL875215
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Inhibitory constant against HIV-1 reverse transcriptase
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis of 2',3'-dideoxynucleoside 5'-alpha-P-borano-beta,gamma-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 7.02 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1383 | DDA-TRIPHOSPHATE | -1.0 | 1 | 7.70 |
| CHEMBL2368437 | — | — | 1 | 7.64 |
| CHEMBL195111 | — | — | 1 | 7.60 |
| CHEMBL2368436 | — | — | 1 | 7.47 |
| CHEMBL370031 | — | — | 1 | 7.43 |
| CHEMBL2368444 | — | — | 1 | 7.35 |
| CHEMBL2368438 | — | — | 1 | 7.34 |
| CHEMBL2368445 | — | — | 1 | 7.33 |
| CHEMBL853 | ZALCITABINE | 4.0 | 1 | 7.29 |
| CHEMBL485652 | STAVUDINE TRIPHOSPHATE | -1.0 | 1 | 7.25 |
| CHEMBL363559 | DEOXYTHYMIDINE_TRIPHOSPHATE | — | 1 | 7.21 |
| CHEMBL2368443 | — | — | 1 | 7.15 |
| CHEMBL191725 | — | — | 1 | 7.15 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | -1.0 | 1 | 7.04 |
| CHEMBL2448386 | — | — | 1 | 7.03 |
| CHEMBL1230 | LAMIVUDINE TRIPHOSPHATE | -1.0 | 1 | 6.73 |
| CHEMBL2368441 | — | — | 1 | 6.63 |
| CHEMBL2368440 | — | — | 1 | 6.50 |
| CHEMBL2368442 | — | — | 1 | 6.36 |
| CHEMBL192771 | — | — | 1 | 6.30 |
| CHEMBL192371 | — | — | 1 | 6.26 |
| CHEMBL2448387 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1383 | DDA-TRIPHOSPHATE | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL2368437 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL195111 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL2368436 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL370031 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL2368444 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL2368438 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL2368445 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL853 | ZALCITABINE | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL485652 | STAVUDINE TRIPHOSPHATE | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL363559 | DEOXYTHYMIDINE_TRIPHOSPHATE | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL2368443 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL191725 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL2448386 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL1230 | LAMIVUDINE TRIPHOSPHATE | Ki | = | 188.0 | nM | 6.73 |
| CHEMBL2368441 | — | Ki | = | 236.0 | nM | 6.63 |
| CHEMBL2368440 | — | Ki | = | 314.0 | nM | 6.50 |
| CHEMBL2368442 | — | Ki | = | 438.0 | nM | 6.36 |
| CHEMBL192771 | — | Ki | = | 501.0 | nM | 6.30 |
| CHEMBL192371 | — | Ki | = | 545.0 | nM | 6.26 |
| CHEMBL2448387 | — | Ki | = | 1770.0 | nM | 5.75 |