Assay Detail
Binding
CHEMBL875404
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human COX-2 expressed in baculovirus infected Sf9 cells
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 2,3-diarylthiophenes as selective Cox-2 and Cox-1 inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.59 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42485 | DUP-697 | — | 1 | 8.30 |
| CHEMBL417204 | — | — | 1 | 8.00 |
| CHEMBL65155 | — | — | 1 | 7.70 |
| CHEMBL303688 | — | — | 1 | 7.52 |
| CHEMBL303870 | — | — | 1 | 7.16 |
| CHEMBL305060 | — | — | 1 | 6.60 |
| CHEMBL308682 | — | — | 1 | 6.39 |
| CHEMBL69053 | — | — | 1 | 6.26 |
| CHEMBL67447 | — | — | 1 | 6.17 |
| CHEMBL303674 | — | — | 1 | 5.80 |
| CHEMBL66445 | — | — | 1 | 5.37 |
| CHEMBL63706 | — | — | 1 | 5.27 |
| CHEMBL292948 | — | — | 1 | 5.14 |
| CHEMBL303036 | — | — | 1 | - |
| CHEMBL302543 | — | — | 1 | - |
| CHEMBL66630 | — | — | 1 | - |
| CHEMBL294050 | — | — | 1 | - |
| CHEMBL63286 | — | — | 1 | - |
| CHEMBL302663 | — | — | 1 | - |
| CHEMBL302687 | — | — | 1 | - |
| CHEMBL293229 | — | — | 1 | - |
| CHEMBL416687 | — | — | 1 | - |
| CHEMBL302950 | — | — | 1 | - |
| CHEMBL63283 | — | — | 1 | - |
| CHEMBL66821 | — | — | 1 | - |
| CHEMBL307983 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42485 | DUP-697 | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL417204 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL65155 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL303688 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL303870 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL305060 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL308682 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL69053 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL67447 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL303674 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL66445 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL63706 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL292948 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL303036 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL302543 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL66630 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL294050 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL63286 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL302663 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL302687 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL293229 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL416687 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL302950 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL63283 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL66821 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL307983 | — | IC50 | > | 30000.0 | nM | - |