Assay Detail
Binding
CHEMBL875659
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Compound was evaluated for the inhibition of Aminoimidazole carboxamide ribonucleotide formyl transferase (AICAR) with (6R) tetrahydrofolate as substrate
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lacticaseibacillus casei |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Bifunctional purine biosynthesis protein ATIC (CHEMBL2518) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
5,10-Methylenetetrahydro-5-deazafolic acid and analogues: synthesis and biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.77 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL331208 | — | — | 1 | 4.77 |
| CHEMBL122959 | — | — | 1 | - |
| CHEMBL123231 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL331208 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL122959 | — | IC50 | > | 95000.0 | nM | - |
| CHEMBL123231 | — | IC50 | > | 40000.0 | nM | - |